3Rs over half a century later- how are we doing?

Russell and Burch's famous book which gave birth to the 3Rs concept that is so important and pervasive in animal-based research today, was published in 1959. So over 60 years later how are we doing in implementing replacement, reduction, and refinement? In this piece by Ellen Neff we learn what the 3Rs means today, how far science has come at incorporating these principles and where further work is needed, illustrated through the eyes of scientists working in the area.

https://www.nature.com/articles/s41684-021-00854-4